The present findings indicate that Siglec-15 is involved in estrogen deficiency-induced differentiation of osteoclasts and is thus a potential therapeutic target for postmenopausal osteoporosis. This study aimed to compare patients undergoing deep extensor muscle-preserving laminoplasty and conventional open-door laminoplasty for the treatment of cervical spondylotic myelopathy (CSM). The LBP group consisted of 71% of non-union and 48% of union cases. Twenty patients with congenital osseous lesions who underwent posterior occipitocervical fusion using the anchors of cervical pedicle screws and plate-rod systems for reduction and fixation from 1996 to 2009 were reviewed. Konomi T, Suda K, Matsumoto S, Komatsu M, Takahata M, Iwasaki N, Minami A, Haraya K, Yamada K, Kokabu T, Iwata A, Endo T, Sudo H, Iwasaki N, Takahata M, Teppei Ito, Masahiko Takahata, Tomohiro Shimizu, Kyosuke Kanazawa, Hiromi Kimura-Suda, Akira Iwata, Masahiko Takahata, Ken Kadoya, Hideaki Sudo, Terufumi Kokabu, Katsuhisa Yamada, Norimasa Iwasaki. 17 beta-Estradiol (E(2); 1040% at 24 weeks into the LBP (n = 36) and non-LBP (n = 31) groups. Conclusion. A retrospective review. Associations among patient age, preoperative health status, surgical factors (instrumentation surgery, operation time, number of spinal levels treated, and estimated blood loss), and perioperative systemic complications were analyzed. Importantly, osteoclasts in Siglec-15(-/-) mice were small and failed to spread on the bone surface, indicating impaired osteoclast differentiation. For even dense HAp products, enhancement of micro-pores and propagation of micro-cracks were recognized by the supersonic treatment for 20 min. Although several chromosomal aberrations and gene muta tions have been reported as disease-causative, these findings have been sparsely replicated to date. Methods. All 9 cases were women who had distal DVT. BP inhibited endochondral ossification and graft bone resorption, but induced the growth of a larger, denser fusion mass compared to Ovx by strongly suppressing osteoclastic activity. There were no complications directly related to CPS insertion. Fujita R, Hamano H, Kameda Y, Arai R, Shimizu T, Ota M, Sato D, Kobayashi H, Iwasaki N, Takahata M, Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi, Toshitaka Yoshii, Shuta Ushio, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii, BACKGROUND: A consensus on the optimal surgical procedure for thoracolumbar OVF has yet to be reached due to the previous relatively small number of case series. The use of multiple coefficients of determination by least squares analysis emphasizes the superiority of combining the bone mineral density and the MRI mapping values in predicting the cancellous bone strength compared with the bone mineral density-based prediction alone. Data on patient demographics were collected, including age, sex, body mass index, smoking, steroid use, medical comorbidities, and surgical procedures. Outcome measures included patient demographics, radiographical measurements, and Scoliosis Research Society questionnaire scores. Late postoperative neurological complications after correction of cervical kyphosis were highly associated with a large amount of kyphosis correction, which may lead foraminal stenosis and enhance posterior drift of the spinal cord. Objective: In two case reports, we describe the circumferential osteotomy of anterior-posterior-anterior surgical sequence, and the efficacy of this technique when cervical pedicle screw fixation for severe fixed cervical kyphosis is used. The simultaneous double-rod rotation technique for treating Lenke 1 AIS provides significant sagittal correction of the main thoracic curve while maintaining sagittal profiles and correcting coronal and axial deformities. Perioperative complications were defined as adverse events that occurred intraoperatively or within 30 days postoperatively. The sensitivity / specificity of FDG-PET/CT was 100% / 79%, respectively, which was superior to those of MRI, 76% / 42%. MicroCT and histologic analyses demonstrated that the 2-week delay in treatment allowed for timely completion of the endochondral phase, such that the prominent effects of PTH134 were enhanced intramembranous bone formation and remodeling at the grafthost junction. In anterior spinal arthrodesis, spinal instrumentation is mainly exposed to bending stress, with decreased load-sharing with corresponding development of the spinal fusion. Radiographic assessment of the sagittal alignment was conducted using lateral radiographs. The femurs were evaluated at 4 and 6 weeks using micro CT, histology, and torsion testing. Furthermore, PTH1-34 has been shown to enhance bone repair in challenged animal models of aging, inflammatory arthritis and glucocorticoid-induced bone loss. Taken together, these data show that DC-STAMP is a potential OCP biomarker in inflammatory arthritis. At 12 weeks of age, BALB/c mice underwent either Sham surgery or bilateral ovariectomy (OVX), and SKG mice underwent intraperitoneal injection of mannan to induce arthritis. Our results bring new insight to the etiology of OPLL. Prediction of bone fragility during progressive collapse following initial fracture is clinically important. Background: Surgical debridement is often required to treat spinal infections. Radiographic union was evaluated independently by three specialists at 24 weeks post-admission. The dissolution efficiency of porous HAp products by the supersonic treatment, which was much higher than that by stirring, drastically increased with time, depending on the porosity of ceramics and the concentration of HNO3 solution. QOL was measured using the EuroQol 5 Dimension (EQ-5D) questionnaire and residual pain using a numeric rating scale (NRS). INTRODUCTION: Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is a rare but serious complication in patients receiving antiresorprtive agents (AR). Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants. The perforation consistently occurred in pedicles in which those axes approached anteroposterior sacral axis within 5 degrees. Administration of levamisole alone and in combination with PPi increased serum PPi concentration by 17% and 52%, respectively, compared to that in vehicle-treated mice. Retrospective analysis of a prospectively collected, consecutive, nonrandomized series of patients. The selective estrogen receptor modulator raloxifene is therapeutically beneficial for postmenopausal connective tissue degradation, such as osteoporosis, vascular sclerosis, and dermal degradation; however, the effects of raloxifene on postmenopausal tendon metabolism have not been clarified. Only the high dose (40 mu g/kg) of PTH134 demonstrated significant effects when given daily over 9 weeks. Flow cytometric analysis also demonstrated that exogenous sialidase effectively removed alpha (2,6)-linked-sialic acid, but only slightly changed the alpha (2,3)-linked-sialic acid content, suggesting that alpha (2,6)-linked-sialic acid might be involved in osteoclast differentiation. CONCLUSION: Patients with AID who undergo dental extraction are at high risk of ARONJ. Masahiko Takahata, Hani A. Awad, Regis J. O'Keefe, Susan V. Bukata, Edward M. Schwarz. Our findings suggest that alpha (2,6)- linked-sialic acid of cell surface glycoconjugates has a role in osteoclast differentiation, possibly via its role in the cell-cell fusion process. Toshiyuki Akazawa, Masaru Murata, Masahiko Takahata, Ding Xianjun, Yuichiro Abe, Katsuo Nakamura, Jun Hino, Junichi Tazaki, Katsutoshi Ito, Manabu Ito, Norimasa Iwasaki, Akio Minami, Takehiko Nakajima, Michiko Sakamoto, Commercial products of hydroxyapatite (HAp) were easily modified to obtain partially-dissolved and precipitated HAp (PDP-HAp) ceramics by the specific dissolution-precipitation technique, which involved a stirring of 300 rpm at 298 K in 1.7-3.4 x 10(-2) N-HNO3 solutions (50 cm(3)) containing Ca2+ and PO43- ions or/and a supersonic treatment at 120 W and 38 kHz in the same solutions. After the stirring of 30 min and the subsequently supersonic treatment of 25 min, HAp nano-crystals with the composition ratio (Ca/P) of 1.64-1.66 were successfully precipitated on the pore wall surface in the macro-pores and micro-pores of the ceramics at 298 K and pH 9-10. Remarkably, equivalent biomechanical results were obtained with delayed, short treatment from 2 to 6 weeks that did not induce a significant increase in endochondral bone formation and callus volume. Results. To obtain safe and favorable results, necessary surgical techniques must be mastered, and surgical equipment, including that for neural monitoring, is required. Miki Komatsu, Kota Suda, Masahiko Takahata, Satoko Matsumoto, Chikara Ushiku, Katsuhisa Yamada, Junichi Yamane, Tsutomu Endo, Norimasa Iwasaki, Akio Minami. Preoperative and follow-up evaluations included the Japanese Orthopaedic Association (JOA) score, a tentative version of the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) including cervical spine function and QOL, and a visual analog scale (VAS) for axial pain. Sialylation of cell surface glycoconjugates is essentianl for cell-cell fusion in osteoclast differentiation. Clinical prediction of bone fracture risk primarily relies on measures of bone mineral density (BMD). The principal healing mechanism of ceramic anterior interbody spinal fusion is not an osseous union between the ceramic and vertebral body, but bridging bone formation around the ceramic, which directly connects the vertebral bodies above and below the disc. Subcutaneous injections of TPD or phosphate-buffered saline (PBS) were performed according to three dosing regimens; 40 A mu g/kg once daily (TPD x 1 group), 40 A mu g/kg three times daily (TPD x 3 group), and PBS (control; Ctl group). To clarify the mechanism of this compensation, we examined whether osteoclast-associated receptor (OSCAR)/Fc receptor common (FcR) signaling, an alternative ITAM-mediated signaling pathway to DAP12, rescues impaired osteoclastogenesis in Siglec-15-deficient cells. For group 1, fibrinogen was applied on the dura followed by PGS and thrombin. Conclusions. Both LDHF-ALN and HDLF-ALN showed therapeutic effects on high bone turnover osteoporosis in CKD stage 4 rats without causing further renal impairment. However, no patient had complaints related to pulmonary function. This technique is applicable not only to it thoracic single curve but also to double major curves in cases of adolescent idiopathic scoliosis. The ligands in type II collagen activate OSCAR and rescue impaired osteoclastogenesis in Siglec-15-deficient cells when cultured on bone slices, indicating that Siglec-15-mediated signaling can be compensated for by signaling activated by type II collagen and other bone matrix components in the primary spongiosa. Assessing trabecular anisotropy might be useful for the evaluation of trabecular health and the validation and refinement of implant designs. RESULTS: Overall perioperative, surgical site, and minor systemic complications were observed in 20.0%, 8.1%, and 14.8% of patients, respectively. Results. METHODS: Sixty-seven patients with single-level thoracolumbar OVF who had not received previous osteoporotic treatment were enrolled. Eighty-four patients were divided into two groups and received either a conventional open-door laminoplasty (CL group) or laminoplasty using a deep extensor muscle-preserving approach (MP group). However, the incidence of ARONJ after tooth extraction in patients with autoimmune disease (AID) remains unclear. This study aimed to compare the techniques of surgical repair of dural tear using bioabsorbable material and fibrin glue. In the radiographic analysis, the anterior vertebral body compression percentage was measured at 0, 12, and 48 weeks. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Medications commenced at 24 weeks of age and continued for 4 weeks. Here we show that rheumatic inflammation deteriorates the bone quality and bone quantity of periarticular bone, thereby decreasing bone strength and toughness in a mouse model of RA. Neither E(2) nor LY117018 significantly altered the expression of type I collagen, which is a main component of the tendon extracellular matrix (ECM), whereas both E(2) and LY117018 significantly increased the expression of matrix metalloproteinase (MMP)-13, which is responsible for tendon collagen degradation in rat. Non-union was correlated with VKA (area under the curve: 0.864). INTRODUCTION: There are considerable risks for the secondary spinal cord injury and the initial and/or delayed vertebral artery occlusion in cases of cervical fracture dislocation. However, a proximal junctional fracture (PJFr) following surgery for OVC can be a serious concern. The JOA recovery rates were statistically equivalent between two groups. Objective. Histologically, however, HDLF-ALN more efficiently suppressed bone turnover, leading to more mineralized trabecular bone, than LDHF-ALN in CKD rats, whereas such differences between LDHF-ALN and HDLF-ALN were not observed in sham rats.